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CZRZ Catalog ID: CZ44
Genotype: nup107tsu068Gt/+
Affected Gene: nup107 (si:dkey-27k7.3, zgc:152723)
Genotyping: pdf
Genomic Feature Construct Lab of Origin Zygosity Parental Genotype
tsu068Gt Gt(bcl2-EGFP) Meng Lab heterozygous
The Nup107–160 multiprotein subcomplex is essential forthe assembly of nuclear pore complexes. Homozygous nup107tsu068Gtmutant embryos exhibit tissue-specific defects after 3 days postfertilization(dpf), including loss of the pharyngeal skeletons,degeneration of the intestine, absence of the swim bladder, andsmaller eyes.In cells of the defective tissues, FGrepeatnucleoporins are disturbed and nuclear pore number isreduced, leading to impaired translocation of mRNAs from thenucleus to the cytoplasm.
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