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CZRZ Catalog ID: MA2
Product: Desmin
Abbreviation: DESM
Isotype: IgG
Cellular Localization: Cytoplasm
Antibody type: Rabbit Polyclonal Antibody
Genecard: Desmin is one of the earliest protein markers for muscle tissue in embryogenesis as it is detected in the somites. Although it is present early in the development of muscle cells, it is only expressed at low levels, and increases as the cell nears terminal differentiation. Desmin is also important in muscle cell architecture and structure since it connects many components of the cytoplasm. Finally, desmin may be important in mitochondria function. Desmin-related myopathy (DRM or Desminopathy) is a subgroup of the myofibrillar myopathy diseases and is the result of a mutation in the gene that codes for desmin which prevents it from forming protein filaments, instead forming aggregates of desmin and other proteins throughout the cell. Recently, mutations were identified in patients suffered by an arrhythmogenic right ventricular cardiomyopathy (ARVC).
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Species Reactivity: Human, mouse, Zebrafish
Antibody Description: pdf
Recommended Dilutions:: WB: 1:1,000-1:2,000 ICC: 1:200 IHC: 1:200
Size: 100ul liquid
Phenotype:
Note:
Desmin
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