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    营利性:¥3500(monclonal antibodies)/Unit  
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CZRC Catalog ID: MA66
Product: HPRT
Abbreviation: HGPRT, HGPRTase, HPRT1, HPRT
Isotype: IgG
Cellular Localization: Cytoplasm.
Antibody type: Recombinant Rabbit Monoclonal Antibody
Genecard: HPRT (hypoxanthine phosphoribosyltransferase 1), also known as HGPRT or HPRT1, is a 218 amino acid cytoplasmic protein that belongs to the purine/pyrimidine phosphoribosyltransferase family. Involved in purine metabolism, HPRT functions as a purine salvage enzyme that catalyzes the conversion of hypoxathine and guanine to their respective mononucleotides (inosine monophosphate and guanosine monophosphate, respectively). HPRT exists as a homotetramer that can bind two magnesium ions as cofactors. Defects in the gene encoding HPRT are the cause of gout and Lesch-Nyhan syndrome (LNS), both of which are characterized by a partial or complete lack of NPRT enzymatic activity. While a partial loss of HPRT enzymatic activity results in a buildup of uric acid (gout), a total loss of enzymatic activity results in hyperuricaemia, mental retardation, choreoathetosis and compulsive self-mutilation, all of which are symptoms associated with LNS. The severity of these diseases suggests an essential role for HPRT in purine metabolism.
NoteInfo: 该抗体为CZRC与杭州华安生物技术有限公司(华安公司)合作开发,在CZRC下单订购即可享有团购价格在线订购时请在上传汇款凭证时上传此文件。CZRC会将有关订单转给华安公司,该抗体订单的付款、发货、售后及服务均由华安公司负责。
* 特别提醒:当您订购抗体时,勿需向CZRC进行支付;因CZRC网站有统一的订购流程,请您在“汇款凭证处”按要求上传此文件即可
Species Reactivity: Human, Mouse, Rat, Zebrafish
Antibody Description: pdf
Recommended Dilutions:: WB: 1:500-1:2,000 IHC: 1:50-1:200 IP: 1:10-1:50
Size: 100ul liquid
Phenotype:
Note:
Hypoxanthine-guanine phosphoribosyltransferase
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