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  • 基准单价:
    非营利性:¥1750(monclonal antibodies)/Unit  
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CZRZ Catalog ID: MA7
Product: FOXO1A
Abbreviation: FOXO1
Isotype: IgG
Cellular Localization: Cytoplasm, Nucleus
Antibody type: Recombinant Rabbit Monoclonal Antibody
Genecard: FKHR (for forkhead in rhabdomyosarcoma) and FKHRL1 are members of the forkhead family of transcription factors. Transcriptional activation of FKHR proteins is regulated by the serine/threonine kinase Akt1, which phosphorylates FKHRL1 and results in FKHRL1 associating with 14-3-3 proteins and being retained in the cytoplasm. Induction of apoptosis or withdrawal of growth factors stimulates dephosphorylation and nuclear translocation of FKHR proteins, leading to FKHR-induced gene-specific transcriptional activation. FKHR, also designated forkhead box protein O1A (FOXO1), is a ubiquitously expressed protein that shuttles between the cytoplasm and nucleus. Genetic mutations in FKHR genes, including the t(2;13) and t(1;3) translocations, are commonly found in alveolar rhabdomyosarcomas. These translocations result in the fusion of the amino terminus of Pax-3 or Pax-7, including the paired box and homeodomain DNA-binding domains, with the carboxy-terminus of FKHR, which contains a transcriptional activation domain. The Pax-3/FKHR fusion protein appears to function as an oncogenic transcription factor that enhances the activation of normal Pax-3 target genes.
NoteInfo: 该抗体为CZRC与杭州华安生物技术有限公司(华安公司)合作开发,在CZRC下单订购即可享有团购价格在线订购时请在上传汇款凭证时上传此文件。CZRC会将有关订单转给华安公司,该抗体订单的付款、发货、售后及服务均由华安公司负责。
* 特别提醒:当您订购抗体时,勿需向CZRC进行支付;因CZRC网站有统一的订购流程,请您在“汇款凭证处”按要求上传此文件即可
Species Reactivity: Human, Mouse, Rat, Zebrafish
Antibody Description: pdf
Recommended Dilutions:: WB: 1:1,000-1:2,000 ICC: 1:50-1:200 IHC: 1:50-1:200
Size: 100ul liquid
Forkhead box protein O1, Forkhead box protein O1A, Forkhead in rhabdomyosarcoma
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