CZRC Catalog ID: |
PA2 |
Product: |
14-3-3 b/a |
Abbreviation: |
KCIP-1 |
Isotype: |
IgG2a |
Cellular Localization: |
Cytoplasm |
Antibody type: |
Mouse Monoclonal Antibody |
Genecard: |
The 14-3-3 proteins are a family of proteins involved in the regulation of apoptosis, mitogenic signaling and cell-cycle checkpoints. The 14-3-3 proteins are thought to be key regulators of signal transduction events mediated through their binding to serine-phosphorylated proteins. Through binding Bad, 14-3-3 prevents apoptosis by sequestering Bad to the cytosol. The 14-3-3 proteins are also Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. They bind to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. |
NoteInfo: |
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Species Reactivity: |
Human, mouse, rat, Zebrafish |
Antibody Description: |
pdf |
Recommended Dilutions:: |
WB: 1:1,000-1:2,000 ICC: 1:100 IHC: 1:200 |
Size: |
100ul liquid |