| CZRC Catalog ID: |
MA13 |
| Product: |
JNK1+JNK2+JNK3 |
| Abbreviation: |
MAP kinase 8/9/10, MAPK 8/9/10, SAPK1c/a/b |
| Isotype: |
IgG |
| Cellular Localization: |
Cytoplasm, Nucleus, Membrane, Mitochondrion |
| Antibody type: |
Recombinant Rabbit Monoclonal Antibody |
| Genecard: |
c-Jun N-terminal kinases (JNKs) phosphorylate and augment transcriptional activity of c-Jun. JNKs originate from three genes that yield 10 isoforms through alternative mRNA splicing, including JNK1a1,JNK1b1, JNK2a1, JNK2b1, and JNK3a1, which represent the p46 isoforms, and JNK1a2, JNK1b2, JNK2a2, JNK2b2, and JNK3b2, which represent the p54 isoforms.JNKs coordinate cell responses to stress and influence regulation of cell growth and transformation. The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83% amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. Capsaicin activates JNK1 and p38 in ras-transformed human breast epithelial cells. Nitrogen oxides (NOx) upregulate JNK1 in addition to c-Fos, c-Jun, and other signaling kinases, including MEKK1 and p38. |
| NoteInfo: |
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* 特别提醒：当您订购抗体时，勿需向CZRC进行支付；因CZRC网站有统一的订购流程，请您在“汇款凭证处”按要求上传此文件即可。 |
| Species Reactivity: |
Human, Mouse, Rat, Cow, Monkey, Zebrafish |
| Antibody Description: |
pdf |
| Recommended Dilutions:: |
WB: 1:1,000-1:5,000 ICC: 1:50-1:200 |
| Size: |
100ul liquid |
